Feedback from Professor Domingue

Zurich, Switzerland, 27th of june 2019

It pleases me to no end that the figure from my published work in I & I, 1974 (utilized as figure 3 in your paper: an electron photomicrograph of a vesiculated mother cell, so clearly helps to define and explain comparable events with C. burnetti that could be operative during infection.  A well done analysis Dr.Kunst. Bravo!  I trust more scientific studies will be forthcoming utilizing the FISH technique to uncover cryptic bacteria, cell wall-defective, as causative agents of disease in chronic conditions suspected of being bacterial in origin and which heretofore have been negative for the presence of bacteria by routine cultural methods of blood in clinical microbiology laboratories. New diagnostic windows have been opened which regrettably have been neglected for too long with bacterial infectious diseases.  Amazingly, it is taking an obscure organism such as Coxiella burnetti to open eyes in resolving such diagnostic issues. I am delighted our fundamental work on bacterial persistence and biological life cycle of cell-wall defective bacteria published in 1974 shows how basic science application of data can be of clinical value.

Gerald J Domingue, professor emeritus

Tulane University

Urology, Microbiology and Immunology (School of Medicine and Graduate studies in basic medical sciences)

New Orleans